{
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  "Package": "mlumr",
  "Title": "Multilevel Unanchored Meta-Regression for Indirect Treatment\nComparisons",
  "Version": "0.2.0",
  "Authors@R": "c(\nperson(\"Ahmad\", \"Sofi-Mahmudi\", , \"a.sofimahmudi@gmail.com\", role = c(\"aut\", \"cre\"),\ncomment = c(ORCID = \"0000-0001-6829-0823\")),\nperson(\"Conor\", \"Chandler\", role = \"aut\",\ncomment = c(ORCID = \"0000-0002-1365-9002\")))",
  "Description": "Bayesian multilevel unanchored meta-regression (ML-UMR)\nfor indirect treatment comparisons using individual patient\ndata (IPD) and aggregate data (AgD). Implements shared\nprognostic factor assumption (SPFA) and relaxed SPFA models for\nbinary, continuous, count, and time-to-event (survival)\noutcomes via 'Stan', including parametric and flexible M-spline\nsurvival baselines. Also provides a one-arm simulated treatment\ncomparison (STC) via comparator-population G-computation and\nnaive unadjusted benchmarks. ML-UMR is an adaptation of the\nML-NMR methodology (Phillippo et al. 2020,\n<doi:10.1111/rssa.12579>) implemented in the 'multinma' package\n(GPL-3) to the unanchored two-trial case. The public API uses\nfamiliar names for data setup, integration and effect\nsummaries, but ML-NMR and ML-UMR specifications and fitted\nobjects are not interchangeable because their evidence\nstructures and models differ.",
  "License": "GPL-3",
  "URL": "https://github.com/choxos/mlumr, https://choxos.github.io/mlumr/",
  "BugReports": "https://github.com/choxos/mlumr/issues",
  "Encoding": "UTF-8",
  "LazyData": "true",
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  "Repository": "https://choxos.r-universe.dev",
  "Date/Publication": "2026-10-13 15:05:17 UTC",
  "RemoteUrl": "https://github.com/choxos/mlumr",
  "RemoteRef": "HEAD",
  "RemoteSha": "ae574a035c2599852aef61740cecf1b2727fa4a6",
  "NeedsCompilation": "yes",
  "Packaged": {
    "Date": "2026-10-13 19:41:35 UTC",
    "User": "root"
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  "Author": "Ahmad Sofi-Mahmudi [aut, cre] (ORCID:\n<https://orcid.org/0000-0001-6829-0823>),\nConor Chandler [aut] (ORCID: <https://orcid.org/0000-0002-1365-9002>)",
  "Maintainer": "Ahmad Sofi-Mahmudi <a.sofimahmudi@gmail.com>",
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  "_expires": "2027-01-21T20:39:44.000Z",
  "_created": "2026-10-13T19:41:35.000Z",
  "_published": "2026-10-13T20:39:46.795Z",
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    "committer": "GitHub <noreply@github.com>",
    "message": "Add the Zenodo DOI badge to the README (#125)\n\nReplace the commented-out DOI placeholder with the Zenodo badge for the concept DOI 10.5281/zenodo.23341927.",
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  "_topics": [
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    "indirect-treatment-comparison",
    "multilevel-models",
    "statistics",
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    "add_integration",
    "calculate_dic",
    "calculate_loo",
    "calculate_waic",
    "check_diagnostics",
    "check_identification",
    "check_integration",
    "combine_data",
    "compare_models",
    "conditional_effects",
    "conditional_predict",
    "dbern",
    "default_prior_aux",
    "default_prior_beta",
    "default_prior_intercept",
    "default_prior_sigma",
    "default_prior_smooth",
    "dgamma",
    "distr",
    "dlogitnorm",
    "geom_km",
    "make_knots",
    "marginal_effects",
    "mlumr",
    "mlumr_engine",
    "mlumr_forest",
    "naive",
    "pbern",
    "pgamma",
    "plogitnorm",
    "plot_prior_posterior",
    "prior_cauchy",
    "prior_exponential",
    "prior_normal",
    "prior_sensitivity",
    "prior_student_t",
    "prior_summary",
    "qbern",
    "qgamma",
    "qlogitnorm",
    "set_agd",
    "set_agd_surv",
    "set_ipd",
    "stc",
    "unnest_integration"
  ],
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      "title": "Dental caries: simulated comparator aggregate data (count)",
      "object": "caries_agd",
      "class": [
        "data.frame"
      ],
      "fields": [
        "study",
        "treatment",
        "n",
        "r",
        "E",
        "age_mean",
        "age_sd",
        "gender_prop",
        "log_cfu_mean",
        "log_cfu_sd"
      ],
      "rows": 1,
      "table": true,
      "tojson": true
    },
    {
      "name": "caries_ipd",
      "title": "Dental caries: simulated index IPD (count)",
      "object": "caries_ipd",
      "class": [
        "data.frame"
      ],
      "fields": [
        "study",
        "treatment",
        "subject",
        "age",
        "gender",
        "log_cfu",
        "dmft",
        "exposure"
      ],
      "rows": 103,
      "table": true,
      "tojson": true
    },
    {
      "name": "ndmm_agd",
      "title": "Newly diagnosed multiple myeloma: comparator pseudo-IPD (survival)",
      "object": "ndmm_agd",
      "class": [
        "data.frame"
      ],
      "fields": [
        "study",
        "treatment",
        "subject",
        "eventtime",
        "status"
      ],
      "rows": 408,
      "table": true,
      "tojson": true
    },
    {
      "name": "ndmm_agd_covs",
      "title": "Newly diagnosed multiple myeloma: comparator covariate summaries (survival)",
      "object": "ndmm_agd_covs",
      "class": [
        "data.frame"
      ],
      "fields": [
        "study",
        "treatment",
        "age_mean",
        "age_sd",
        "iss_stage3_prop",
        "response_cr_vgpr_prop",
        "male_prop"
      ],
      "rows": 1,
      "table": true,
      "tojson": true
    },
    {
      "name": "ndmm_ipd",
      "title": "Newly diagnosed multiple myeloma: index individual patient data (survival)",
      "object": "ndmm_ipd",
      "class": [
        "data.frame"
      ],
      "fields": [
        "study",
        "treatment",
        "subject",
        "age",
        "iss_stage3",
        "response_cr_vgpr",
        "male",
        "eventtime",
        "status"
      ],
      "rows": 231,
      "table": true,
      "tojson": true
    },
    {
      "name": "psoriasis_agd",
      "title": "Plaque psoriasis: comparator aggregate data (binary)",
      "object": "psoriasis_agd",
      "class": [
        "data.frame"
      ],
      "fields": [
        "study",
        "treatment",
        "pasi75_r",
        "pasi75_n",
        "age_mean",
        "age_sd",
        "bsa_mean",
        "bsa_sd",
        "weight_mean",
        "weight_sd",
        "prevsys_prop"
      ],
      "rows": 1,
      "table": true,
      "tojson": true
    },
    {
      "name": "psoriasis_ipd",
      "title": "Plaque psoriasis: index individual patient data (binary)",
      "object": "psoriasis_ipd",
      "class": [
        "data.frame"
      ],
      "fields": [
        "study",
        "treatment",
        "subject",
        "pasi75",
        "age",
        "bsa",
        "weight",
        "prevsys"
      ],
      "rows": 347,
      "table": true,
      "tojson": true
    },
    {
      "name": "shoulder_agd",
      "title": "Shoulder pain: simulated comparator aggregate data (continuous)",
      "object": "shoulder_agd",
      "class": [
        "data.frame"
      ],
      "fields": [
        "study",
        "treatment",
        "n",
        "y_mean",
        "y_se",
        "age_mean",
        "age_sd",
        "sex_prop",
        "baseline_vas_mean",
        "baseline_vas_sd"
      ],
      "rows": 1,
      "table": true,
      "tojson": true
    },
    {
      "name": "shoulder_ipd",
      "title": "Shoulder pain: simulated index IPD (continuous)",
      "object": "shoulder_ipd",
      "class": [
        "data.frame"
      ],
      "fields": [
        "study",
        "treatment",
        "subject",
        "age",
        "sex",
        "baseline_vas",
        "pain_vas_activity"
      ],
      "rows": 147,
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "add_integration",
      "title": "Add numerical integration points",
      "topics": [
        "add_integration"
      ]
    },
    {
      "page": "calculate_dic",
      "title": "Calculate DIC for model comparison",
      "topics": [
        "calculate_dic"
      ]
    },
    {
      "page": "calculate_loo",
      "title": "Calculate LOO-CV for an mlumr_fit",
      "topics": [
        "calculate_loo"
      ]
    },
    {
      "page": "calculate_waic",
      "title": "Calculate WAIC for an mlumr_fit",
      "topics": [
        "calculate_waic"
      ]
    },
    {
      "page": "caries_agd",
      "title": "Dental caries: simulated comparator aggregate data (count)",
      "topics": [
        "caries_agd"
      ]
    },
    {
      "page": "caries_ipd",
      "title": "Dental caries: simulated index IPD (count)",
      "topics": [
        "caries_ipd"
      ]
    },
    {
      "page": "check_diagnostics",
      "title": "Check the sampler diagnostics of a fit",
      "topics": [
        "check_diagnostics"
      ]
    },
    {
      "page": "check_identification",
      "title": "Can the aggregate data identify the comparator coefficients?",
      "topics": [
        "check_identification"
      ]
    },
    {
      "page": "check_integration",
      "title": "Check integration point adequacy",
      "topics": [
        "check_integration"
      ]
    },
    {
      "page": "combine_data",
      "title": "Combine IPD and AgD for unanchored comparison",
      "topics": [
        "combine_data"
      ]
    },
    {
      "page": "compare_models",
      "title": "Compare fitted ML-UMR models",
      "topics": [
        "compare_models"
      ]
    },
    {
      "page": "conditional_effects",
      "title": "Conditional treatment effects",
      "topics": [
        "conditional_effects"
      ]
    },
    {
      "page": "conditional_predict",
      "title": "Conditional predictions",
      "topics": [
        "conditional_predict"
      ]
    },
    {
      "page": "dbern",
      "title": "Bernoulli PMF",
      "topics": [
        "dbern"
      ]
    },
    {
      "page": "default_priors",
      "title": "Default priors used by 'mlumr()'",
      "topics": [
        "default_priors",
        "default_prior_aux",
        "default_prior_beta",
        "default_prior_intercept",
        "default_prior_sigma",
        "default_prior_smooth"
      ]
    },
    {
      "page": "distr",
      "title": "Specify a marginal distribution",
      "topics": [
        "distr"
      ]
    },
    {
      "page": "GammaDist",
      "title": "The Gamma distribution, parameterized by mean and standard deviation",
      "topics": [
        "dgamma",
        "GammaDist",
        "pgamma",
        "qgamma"
      ]
    },
    {
      "page": "geom_km",
      "title": "Observed Kaplan-Meier layer for survival overlays",
      "topics": [
        "geom_km"
      ]
    },
    {
      "page": "logitNormal",
      "title": "The logit-Normal distribution",
      "topics": [
        "dlogitnorm",
        "logitNormal",
        "plogitnorm",
        "qlogitnorm"
      ]
    },
    {
      "page": "make_knots",
      "title": "Choose M-spline knots for a flexible-baseline survival model",
      "topics": [
        "make_knots"
      ]
    },
    {
      "page": "marginal_effects",
      "title": "Marginal treatment effects",
      "topics": [
        "marginal_effects"
      ]
    },
    {
      "page": "mlumr",
      "title": "Fit ML-UMR Model",
      "topics": [
        "mlumr"
      ]
    },
    {
      "page": "mlumr_engine",
      "title": "Get or set the Stan engine",
      "topics": [
        "mlumr_engine"
      ]
    },
    {
      "page": "mlumr_forest",
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