Package: mlumr
Title: Multilevel Unanchored Meta-Regression for Indirect Treatment
        Comparisons
Version: 0.2.0
Authors@R: c(
    person("Ahmad", "Sofi-Mahmudi", , "a.sofimahmudi@gmail.com", role = c("aut", "cre"),
           comment = c(ORCID = "0000-0001-6829-0823")),
    person("Conor", "Chandler", role = "aut",
           comment = c(ORCID = "0000-0002-1365-9002")))
Description: Bayesian multilevel unanchored meta-regression (ML-UMR)
        for indirect treatment comparisons using individual patient
        data (IPD) and aggregate data (AgD). Implements shared
        prognostic factor assumption (SPFA) and relaxed SPFA models for
        binary, continuous, count, and time-to-event (survival)
        outcomes via 'Stan', including parametric and flexible M-spline
        survival baselines. Also provides a one-arm simulated treatment
        comparison (STC) via comparator-population G-computation and
        naive unadjusted benchmarks. ML-UMR is an adaptation of the
        ML-NMR methodology (Phillippo et al. 2020,
        <doi:10.1111/rssa.12579>) implemented in the 'multinma' package
        (GPL-3) to the unanchored two-trial case. The public API uses
        familiar names for data setup, integration and effect
        summaries, but ML-NMR and ML-UMR specifications and fitted
        objects are not interchangeable because their evidence
        structures and models differ.
License: GPL-3
URL: https://github.com/choxos/mlumr, https://choxos.github.io/mlumr/
BugReports: https://github.com/choxos/mlumr/issues
Encoding: UTF-8
LazyData: true
LazyDataCompression: xz
Roxygen: list(markdown = TRUE)
Biarch: true
Depends: R (>= 4.1.0)
Imports: methods, stats, Rcpp (>= 0.12.0), RcppParallel (>= 5.0.1),
        rstan (>= 2.26.0), rstantools (>= 2.3.0), randtoolbox, survival
        (>= 3.1-0), splines2 (>= 0.4.1), ggplot2 (>= 3.4.0)
LinkingTo: BH (>= 1.66.0), Rcpp (>= 0.12.0), RcppEigen (>= 0.3.3.3.0),
        RcppParallel (>= 5.0.1), rstan (>= 2.26.0), StanHeaders (>=
        2.26.0)
Suggests: testthat (>= 3.2.0), ggsurvfit, knitr, rmarkdown, posterior,
        bayesplot, loo, Matrix, cmdstanr, withr, flexsurv,
        detectseparation, xfun, R.rsp
Additional_repositories: https://mc-stan.org/r-packages
SystemRequirements: GNU make
Config/testthat/edition: 3
VignetteBuilder: knitr, R.rsp
Config/roxygen2/version: 8.1.0
Config/pak/sysreqs: cmake make
Repository: https://choxos.r-universe.dev
Date/Publication: 2026-10-13 15:05:17 UTC
RemoteUrl: https://github.com/choxos/mlumr
RemoteRef: HEAD
RemoteSha: ae574a035c2599852aef61740cecf1b2727fa4a6
NeedsCompilation: yes
Packaged: 2026-10-13 19:41:35 UTC; root
Author: Ahmad Sofi-Mahmudi [aut, cre] (ORCID:
    <https://orcid.org/0000-0001-6829-0823>),
  Conor Chandler [aut] (ORCID: <https://orcid.org/0000-0002-1365-9002>)
Maintainer: Ahmad Sofi-Mahmudi <a.sofimahmudi@gmail.com>